Ph.D. Northwestern University, Neuroscience
B.A. Lawrence University, Biology and Neuroscience
My laboratory investigates how individual neurons wire themselves together into a precisely interconnected and functional nervous system.
Specifically, the lab is interested in how growth factors direct axon extension and innervation, growth cone dynamics, and the elaboration of axonal and dendritic arbors. Our neuron of choice is the retinal ganglion cell (RGC), the only neuron that connects the eye to the brain. These connections must be formed with extreme precision in order for an organism to see. RGC cell bodies and dendrites reside in the retina, while thier axons follow a stereotypic pathway to synapse in the brain. We can manipulate and observe developing RGCs particularly well in the South African claw-toed frog (Xenopus laevis).
My laboratory also investigates the role of the cholinergic signaling in developing spinal neurons. We use transgenic zebrafish embryos to understand how pesticides influence neurogenesis and axon guidance.
Finally, our most recent project in the lab examines the role of Stitrks, a novel family of genes, in zebrafish nervous system development.
Bio 111 Molecules, Genes, & Cells
Bio 251 Light Microscopy (Group Investigation)
Bio 261 Neuroscience of Exercise (Seminar)
Bio 306 Developmental Biology
Bio 333 Cellular & Molecular Neuroscience
Bio 371 Independent Research