This discussion will focus on the topic of molecules. Molecules such as D-Mannose and D-galactose mono-, di- and trisaccharides with thiol (SH)-terminated aglycons and aglycons that are constructed by glycosylation of appropriately protected glycosyl donors and acceptors, followed by (1) free-radical addition to introduce the thiol terminals onto the aglycons or form tethers with other functionalized groups. Subsequent deprotection afforded the free-OH saccharides. Tethering chemistries allow these components to be attached to gold-clad silicon chips, creating carbohydrate surfaces of varying valencies and densities.
Chambers Hance Auditorium (CHAM-4121)
Yates, Alexis C